After a 14-month absence, Andy Murray returns to 2018 US Open Grand Slam and will compete with James Duckworth.
The past world No.1, currently ranked 378, could fight in the 3rd round with Juan Martin del Potro.
Kyle Edmund, his substitution as British number 1, compete Italy's Paolo Lorenzi, whereas Cameron Norrie meets Australian Jordan Thompson.
Johanna Konta has an extreme match against French 6th seed Caroline Garcia.
English No. 1 Konta, twenty-seven, has gone down to 46 in the positions following a year in which she has attempted to discover consistency.
Katie Swan and Heather Watson confront each other in qualifying on Friday for a place in the main draw, however, Naomi Broady is out, as is sibling Liam in the men's draw.
On Monday the fourth and last major of the year, Grand Slam the US Open will start in New York.